After the abduction and assumed death of Mackenzie Allen Phillip's youngest daughter, Missy, Mack receives a letter and has the suspicion it's from God asking him to return to The Shack where Missy may have been murdered. After contemplating it, he leaves his home to go to The Shack for the first time since Missy's accident and encounters what will change his life forever.
艾利（约翰·C·赖利 John C. Reilly 饰）和查理（华金·菲尼克斯 Joaquin Phoenix 饰）是一对杀手兄弟，某日，他们接到了一项任务，去暗杀一名淘金者。于是，两个男人火速从俄勒冈前往旧金山，一路上，两个人遇到的麻烦可不少，但他们凭借着智慧和勇气将它们一一化解，最终安全的抵达了目的地。
当他们见到了他们的目标时才发现，这个名叫沃姆（里兹·阿迈德 Riz Ahmed 饰）的男人是一名化学家，他发明出了一种神奇的药剂，可以帮助人们更快速的寻找到金矿的所在。两利相权取其重，艾利和查理当即决定辞去杀手这份工作，转而成为来钱更快的淘金汉，哪知道他们为这个鲁莽的决定付出了沉重的代价
